It would be a solid investment at the most important position on the team. The Niners coaching staff has seen both Flacco and Henne at Senior Bowl week, and has a good idea what they're capable of. Both have strong arms and good accuracy, Henne is more polished while Flacco has more upside (and more risk).
ROT (Cherilus?) with the 1st pick, QB (Henne?) with the 2nd.
Not the most likely pair of picks, but an intriguing one.