I just guessed now, so don't hold me to this (especially without seeing any preseason) games.
But this is a tough schedule. Especially for a team that didn't make the playoffs last year.

I count at least 6 difficult games with playoff caliber teams. 10 wins would mean a clean sweep of everyone else (including everyone in the NFC West)

Sep 07 ARI @ SF W
Sep 14 SF @ SEA L
Sep 21 DET @ SF W
Sep 28 SF @ NO L
Oct 05 NE @ SF L
Oct 12 PHI @ SF L
Oct 19 SF @ NYG L
Oct 26 SEA @ SF W
Bye
Nov 10 SF @ ARI L
Nov 16 STL @ SF W
Nov 23 SF @ DAL L
Nov 30 SF @ BUF W
Dec 07 NYJ @ SF L
Dec 14 SF @ MIA W
Dec 21 SF @ STL L
Dec 28 WAS @ SF L